NSF 25-522: EPSCoR Research Infrastructure Improvement Program: EPSCoR Research Incubators for STEM Excellence (E-RISE)

Sponsor: NSF
Internal Deadline: 05/22/2026
Institutional Submission Limit: 1
Program Website

The Established Program to Stimulate Competitive Research (EPSCoR) supports the mission of the U.S. National Science Foundation (NSF) by promoting nationwide scientific progress. Through this program, NSF fosters partnerships among academic institutions, government entities, industry, and non-profits. These collaborations aim to drive long-term improvements in research infrastructure, enhance R&D capacity, and boost the research competitiveness of eligible EPSCoR jurisdictions, including states, territories, and commonwealths.

A jurisdiction's research ecosystem is the interconnected network of institutions, organizations, researchers, trainees, community stakeholders, and resources that contribute to the process of research and innovation that advances fundamental knowledge, generates use-inspired products, and ultimately cultivates beneficial societal impacts for a jurisdiction. E-RISE supports hypothesis-driven or problem-driven research and fosters the development of research teams and products in a scientific topical area that aligns with a jurisdiction's research ecosystem and priorities, as detailed in the jurisdiction's Science and Technology (S&T) Plan or drawn from other jurisdiction plans, reports, or publications prepared by appropriate authorities or bodies. E-RISE invites innovative proposals within the chosen research area that will lead to development and implementation of sustainable broad networks of individuals, institutions, and organizations, and that will transform the science, technology, engineering and mathematics (STEM) research capacity and competitiveness in a jurisdiction. E-RISE is particularly interested in proposals that justify exploring emerging or interdisciplinary research areas with high potential impact.

E-RISE projects must have a clearly articulated research goal that will lead to new knowledge by addressing a clear hypothesis or problem. The E-RISE project should promote (i) areas of research capacity-building within a chosen research topic; (ii) development of a skilled workforce that is relevant to the research topic, as well as the project and its outcomes; (iii) a culture of collaboration and engagement across different types of academic institutions and organizations, as well as non-academic sectors (e.g., industry and government); (iv) integration of the research with societal impacts; and (v) a clear sustainability plan to preserve the resulting research incubator's team and products beyond E-RISE funding.

Only one submission per organization is allowed where the organization serves as the lead either on a single proposal with subawards or as the lead on a set of separately submitted collaborative proposals.

 

**Eligibility Disclaimer: An E-RISE submitted in the previous cycle is currently in review at the NSF, and if awarded, USC will not be eligible to submit. We are still holding the internal limited submission competition in case USC becomes eligible to submit to the August 2026 cycle. 

Submission Process

Limited submissions MUST be coordinated with the Office of the Vice President for Research.

If interested in applying for this opportunity, please combine the following items into a single PDF and email to resdev@mailbox.sc.edu by 5pm on the INTERNAL DEADLINE above:

• Cover page with grant program name & number (if applicable) to which you are applying, your project title, PI (name, department/unit, & email), and list of co-PIs/key collaborators (name & department/unit)
• a two-page project abstract addressing key components/criteria for this specific grant program
• a 2-3 page CV/biosketch for the PI (SCiENcv preferred)